Who would say no to this question? (I see no one has) But They go threw HELl, and both of them have been to Hell. Some people might go insane from that. Sam and Dean have to deal with not having family (besides each other, which is all the need, but still) or friends that they don;t have to worry about. They fight monsters, there is not much room to be weak. There Stronger then most men could ever dream to be.

The most strtong persons on world

they are the strongest persons ever not just physically but mentally and emotionally too, could u imagine going to Hell literally? and don't turn crazy,having to deal with death of your parents,girlfriend and the closest thing they have to a family (Ellen and JO)and feeling responsible of the end of the world

They make every thing u go throw no matter how difficult it is,seams like nothing compared to what they go throw everyday and they make u appreciate the things u have in life even more,

Absolutely. WHO PICKED NO? *cocks shotgun*

How the hell could they not be?

Whoever picked 'No' must be crazy.