Easily IMO. They are are one of the absolute most interesting things about the show.

Then:

Lodge family
Coopers
Andrews
Jones family.

But they are all interesting.

I feel like the Blossoms will be the more popular choice, but to me, the Coopers are the more interesting family. Cheryl is an interesting character, but we still know very little about Jason and her parents have little depth. Meanwhile, all the Coopers are complex and often morally grey characters.

Cooper
Jones
Blossom
Lodge
Andrews

I really don't like the Coopers, they might be a bit interesting, but at the same time they have that boring sweetheart, perfect vibe.

^I don't agree with that. Cheryl is super interesting, the fact that we know less about Jason that other main characters, but enough to care and want to know more, makes him a mystery too. Also, half the mysteries and investigation is about the Blossoms, they're definitely the most mysterious, the ones hiding a lot more than every other family. And even their house and everything about it, their Sirup and the beautiful relationship between Cheryl and Jason.

For me personally:

Blossoms
Lodge
Andrews
Cooper - I hate/dislike them, but they're more interesting than Jughead's family who we barely know one thing about.
Jones

Definitely! The Lodge Family is a close second

The Andrews!