A man's left brain and right brain operate independently, which means he lives with two different personalities and has no control over his actions. This makes diagnosing him doubly challenging, as the two sides of his brain struggle for dominance and it becomes increasingly difficult for House and his team to figure out the problem. As a result, the team comes up with some "alternative methods" to get him to cooperate.
In the meantime, Cuddy also must find an unusual approach to convince House to complete his clinic hours.